Cheap flights from Knoxville to Chicago O'Hare International

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Flight deals from Knoxville to Chicago O'Hare International

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Chicago O'Hare International Airport? If you want to travel next month, return fares start from $273. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to Chicago O'Hare International

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Chicago O'Hare International flights are currently cheapest in June.

Direct flights from Knoxville to Chicago O'Hare International

Knoxville to Chicago O'Hare International: Alternative routes

Compare routes from Knoxville to Chicago below. You may find an airport to fly into that's cheaper, faster, or easier than Chicago O'Hare International.

Knoxville to Chicago: Flight information

The things to know before you go.
Cheapest flight found$139
Cheapest month to flyJune
Average flight time2 hrs, 5 mins
Most popular airlineAmerican Airlines
Average flights per week330

Finding cheap flights from Knoxville to Chicago O'Hare International: Frequently asked questions

The best price we found for a return flight from Knoxville to Chicago O'Hare International is $273. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 5 minutes is the average flight time from Knoxville to Chicago O'Hare International.
American Airlines, SkyWest Airlines and United fly direct from Knoxville to Chicago O'Hare International.
As of May 2026, there are 330 flights per week flying from Knoxville to Chicago O'Hare International.
The cheapest month to fly from Knoxville to Chicago O'Hare International is usually June.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Chicago O'Hare International Airport on Monday, 15 June 2026.
Yes – the average flight time is 2 hours and 5 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Chicago O'Hare International but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Chicago is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Allegiant Air and United offer the cheapest flight tickets to Chicago O'Hare International.

Travelling from McGhee Tyson Airport (TYS) to O'Hare International Airport (ORD): what you need to know

  • Take a direct flight from McGhee Tyson Airport to O'Hare International Airport and you'll be in the air for an average of 2 hours.

  • The timezone in Chicago is UTC-5, which is one hour behind Knoxville.

  • Take your pick of 70 weekly McGhee Tyson Airport to O'Hare International Airport flights. The 07:00 departure with United Airlines is the earliest available. United Airlines operates the last service of the day at 18:55.

  • Give yourself plenty of time to catch your TYS to ORD flight. A good rule of thumb is to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • During popular months such as July, you'll want to get to the airport even earlier. Plan to arrive two hours before domestic departures and four hours ahead of international flights when you fly during a high season in general.

  • Jetting into Chicago (and then discovering more of United States!) is a snap with American Airlines. This popular airline offers direct flights from McGhee Tyson Airport to O'Hare International Airport.

  • The airline that passengers book most often on this route is American Airlines.

  • United Airlines is the most punctual carrier operating TYS to ORD flights. An exceptional 83.57% of its services on this route arrive without delay.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to O'Hare International Airport (ORD)

  • The lowest price we've found for a one-way McGhee Tyson Airport to O'Hare International Airport flight is $139. A round-trip ticket right now is $273. Depending on the availability when you book, these fares can change.

  • To pick up cheap tickets from TYS to ORD, book your journey six months ahead of your departure.

  • The cheapest month for flights from McGhee Tyson Airport to O'Hare International Airport is May. Use the 'Whole month' tool to find the lowest prices if you have flexible dates.

  • Landing cheap flights from TYS to ORD couldn't be easier with Price Alerts. All you need to do is set up one of these automatic alerts and we'll notify you as soon as fares go down.

  • Tailor your flights using filters. Select your departure and arrival times, total journey duration and airlines. You can also sort your results by 'Best,' 'Cheapest' or 'Fastest' flights from McGhee Tyson Airport to O'Hare International Airport.

Handy information about McGhee Tyson Airport (TYS)

  • TYS is located at 2055 Alcoa Highway.

  • Of all flights departing from McGhee Tyson Airport, 78.98% land on time at their destination.

  • To reach McGhee Tyson Airport from central Knoxville, it'll take around 20 minutes if you're going by car. Of course, this depends on traffic. It's approximately 23 kilometres from the airport to the city centre.

  • Taking an early flight from McGhee Tyson Airport to O'Hare International Airport? Avoid the stress of rushing to the terminal (and sneak in some extra precious sleep) by choosing one of these stays close to TYS:

Arriving at O'Hare International Airport (ORD)

Getting from O'Hare International Airport (ORD) to central Chicago

  • You'll find ORD at 10000 West O'Hare.

  • O'Hare International Airport is roughly 40 kilometres from central Chicago. The drive time takes around 35 minutes.

  • Travelling to the centre on public transport takes about 55 minutes.

When to fly to O'Hare International Airport (ORD)

  • August is the busiest month for flights from McGhee Tyson Airport to O'Hare International Airport. For smaller crowds, visit Chicago in January.

  • Book your flight from McGhee Tyson Airport to O'Hare International Airport for July if you want to go to Chicago during its warmest month. Expect temperatures of between 15ºC (59ºF) and 29ºC (84ºF).

  • Look for cheap tickets from TYS to ORD in January if you'd rather travel during cooler conditions. Temperatures are at their lowest around then, ranging between -12ºC (10ºF) and 3ºC (37ºF) on average.

Explore more of United States

  • You've done Chicago, now it's time to discover more of United States. Journey around 451 kilometres south-east to Columbus to check off its leading attractions. From Franklin Park Conservatory and Botanical Gardens to Ohio Statehouse and German Village, your itinerary will be busy.

  • Indianapolis is another favourite destination in United States and is around 257 kilometres south-east of Chicago. No journey is complete without dropping by The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.