Cheap Flights from Chicago to South Carolina from $179 Return

Flight deals from Chicago to South Carolina

Looking for cheap tickets from Chicago to South Carolina, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Charleston.$179 per passenger.Departing Sat, 11 Apr, returning Tue, 14 Apr.Return flight with Spirit Airlines.Outbound indirect flight with Spirit Airlines, departs from Chicago O'Hare International on Sat, 11 Apr, arriving in Charleston.Inbound indirect flight with Spirit Airlines, departs from Charleston on Tue, 14 Apr, arriving in Chicago O'Hare International.Price includes taxes and charges.From $179, select.

Myrtle Beach.$187 per passenger.Departing Tue, 14 Apr, returning Wed, 22 Apr.Return flight with Spirit Airlines.Outbound indirect flight with Spirit Airlines, departs from Chicago O'Hare International on Tue, 14 Apr, arriving in Myrtle Beach International .Inbound indirect flight with Spirit Airlines, departs from Myrtle Beach International on Wed, 22 Apr, arriving in Chicago O'Hare International.Price includes taxes and charges.From $187, select.

Greenville.$187 per passenger.Departing Thu, 30 Apr, returning Sun, 3 May.Return flight with Delta.Outbound indirect flight with Delta, departs from Chicago O'Hare International on Thu, 30 Apr, arriving in Greenville-Spartanburg.Inbound indirect flight with Delta, departs from Greenville-Spartanburg on Sun, 3 May, arriving in Chicago O'Hare International.Price includes taxes and charges.From $187, select.

Columbia.$266 per passenger.Departing Sat, 10 Oct, returning Sat, 24 Oct.Return flight with United.Outbound direct flight with United departs from Chicago O'Hare International on Sat, 10 Oct, arriving in Columbia Metropolitan.Inbound direct flight with United departs from Columbia Metropolitan on Sat, 24 Oct, arriving in Chicago O'Hare International.Price includes taxes and charges.From $266, select.

Hilton Head Island.$340 per passenger.Departing Fri, 15 May, returning Fri, 22 May.Return flight with Delta.Outbound indirect flight with Delta, departs from Chicago O'Hare International on Fri, 15 May, arriving in Hilton Head.Inbound indirect flight with Delta, departs from Hilton Head on Fri, 22 May, arriving in Chicago O'Hare International.Price includes taxes and charges.From $340, select.

See more deals

Flying from Chicago to South Carolina

Arm yourself with these facts on the fly.

Cheapest flight found	$179
Cheapest month to fly	April
Average flight time	2 hrs, 9 mins
Cheapest airport to fly from	Chicago O'Hare International
Most popular airline	United

How to find cheap flights from Chicago to South Carolina

We've compared the best online travel agents and flight providers on the internet to find the cheapest plane tickets from Chicago to South Carolina. Other savvy travellers recently found return flights from $179 and one-way tickets from $83 one-way. Ready to join them? Here are a few tips to help you do it the smart way.

Fly from Chicago O'Hare International into Charleston

At the moment, the lowest priced flight tickets to South Carolina are from Chicago O'Hare International Airport to Charleston Airport.

Fly in April

We crunched the flight calendar and found the cheapest time to fly from Chicago to South Carolina is currently April.

Flex your dates for the best rates

If you’re flexible on your departure dates, you can use Skyscanner's whole month tool to find the cheapest day of the year to fly from Chicago to anywhere you choose in South Carolina.

Watch as fares rise and fall

With Price Alerts, we'll let you know when flight prices from Chicago to South Carolina go up or down so you can book when the time is just right.

Relax – these are fee-free flight tickets

With us, there are no added fees – the South Carolina to South Carolina flight price you see when you search with us is what you pay to the provider.

Frequently asked questions

What's the average Chicago to South Carolina flight price?

We looked at all of the upcoming return flights from Chicago to South Carolina we could find over the next 12 months. It looks like $179 is the best price. This is good, compared to the average South Carolina ticket price of $232.

What is the cheapest month to fly from Chicago to South Carolina?

The cheapest month to fly from Chicago to Greenville-Spartanburg Airport is usually April. The cheapest month to fly from Chicago to Myrtle Beach International Airport is usually April. The cheapest month to fly from Chicago to Hilton Head Airport is usually May. And the cheapest month to fly from Chicago to Columbia Metropolitan Airport is usually October.

Which upcoming date is cheapest to fly from Chicago to South Carolina on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Chicago to South Carolina on Saturday, 11 April 2026.

Are there any direct flights from Chicago to South Carolina?

Chicago O'Hare International Airport and Chicago Midway Airport all offer direct flights to South Carolina.

If I'm flying from Chicago, where in South Carolina is cheapest to fly into?

If you're flying from Chicago, the cheapest city in South Carolina to fly into is Charleston. The cheapest airport serving Charleston at the moment is Charleston.