Unless your coming here to see a baseball or football game then stay home. Odds are your home town is nicer.
The city is filled with so much culture. Booming with young professionals, the happy-hour options are endless.
The Cincinnati Symphony Orchestra is world class, the Museum Center is perhaps the most people friendly museum in America and the people are hospitable. On the other hand there should be more to a city's cuisine than steak houses and pizza joints and the number of panhandlers and homeless make San Francisco look as though the question is a non issue.
It was a fun trip on "New Years". From cafes, to restraints, to the night life. It was so grand a bit coastly though, parking is a hassle hard to find and expensive. I really enjoyed the big city, for the most part it was clean and safe the areas I was in anyway.